Structure-activity Relationships of Herbicidal 5-Ethylamino- and 5-Propylamino-2, 3-Dicyanopyrazines

Abstract

Sixty-eight 6-substituted 5-ethylamino and 5-propylamino-2, 3-dicyanopyrazines were synthesized and their herbicidal activities against barnyard grass were measured in pot tests.The most active compound was 2, 3-dicyano-5-propylamino-6-(m-chloro phenyl) pyrazine.The activities of the two series of compoundswere analyzed quantitatively using the hydrophobic and steric parameters of substituents at the 6-position of the pyrazine ring and an indicator variable.