Formation of 4-Hydroxy-3, 7-dimethyl-2, 6-octadienal (5-Hydroxycitral) from 3, 7-Dimethyl-2, 6-octadienal (Citral) and its Biological Activity against Sarcoma 180

Abstract

4-Hydroxy-3, 7-dimethyl-2, 6-octadienal (5-Hydroxycitral) (2) was prepared from 3, 7-dimethyl-2, 6-octatrienal (citral) (1) via bromoaldehyde (4) and acetoxyaldehyde (6). 3, 7-Dimethyl-2, 4, 6-octadienal (7) was also obtained as a byproduct. 4-Hydroxy-3, 7-dimethyl-2, 6-octadienal (2) showed similar growth inhibition activity to that of 1 against Sarcoma180.