Carbon Catabolite Regulation of Neoviridogrisein Production by Glucose

Abstract

The production of neoviridogrisein II, a peptidolactone antibiotic, was suppressed by glucose in Streptomyces griseoviridus G-89. Pyruvic acid accumulated in the glucose-supplemented culture. The glucose effect was correlated with inhibition by pyruvic acid but not with low pH of the culture broth.