Synthesis of ω-Chain Shortened Prostaglandins and Their Six-membered Ring Analogs

Yoshinobu NAOSHIMA; Takayoshi TAKEHI; Kiyoshi DOI; Shoji WAKABAYASHI; Shuichi HAYASHI

doi:10.1271/bbb1961.48.783

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Synthesis of ω-Chain Shortened Prostaglandins and Their Six-membered Ring Analogs

Yoshinobu NAOSHIMA, Takayoshi TAKEHI, Kiyoshi DOI, Shoji WAKABAYASHI, Shuichi HAYASHI

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JOURNAL FREE ACCESS

1984 Volume 48 Issue 3 Pages 783-787

DOI https://doi.org/10.1271/bbb1961.48.783

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Abstract

Prostaglandin E₁ analogs 5a and 5b, having methyl and ethyl groups as the co-chain, were synthesized by a two-step alkylation system of diethyl 3-oxoglutarate (1) and their six-membered ring analogs 8a and 8b also derived from the first alkylation product 2 via a Michael reaction.

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