A Useful and Biomimetic Synthesis of N-Acyl α, β-Dehydroalanine from Aspartic Acid

Abstract

N-Acyl α, β-dehydroalanines (1) were synthesized from the corresponding N-acyl aspartic acids by a one-pot procedure through a biomimetic oxidative β-decarboxylation. In particular, the transformation using methanol-sodium hypochlorite aqueous solution, which served for N-chlorination and dehydrochlorination, afforded good yields of (1).