Biosynthesis of Enduracidin: Origin of Enduracididine and Other Amino Acids

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The biosynthetic origin of the amino acid moieties of enduracidin was investigated by feeding experiments with labeled compounds. Results of the incorporation and the distribution of radioactivity into the antibiotic revealed that glycine, L-serine, L-threonine, L-alanine, L-aspartic acid, L-ornithine and L-citrulline were incorporated into the corresponding amino acid moieties. Unique amino acids, enduracididine and its isomer with an imidazolidine ring, were derived from larginine, but not histidine. K₁ (4-hydroxyphenylglycine) and K₂ (3, 5-dichloro-K₁) moieties were derived from L-tyrosine. ³⁶Cl-Sodium chloride was incorporated into the antibiotic in the early stage of fermentation.