1984 Volume 48 Issue 7 Pages 1777-1781
The absorbability of polyethylene glycol (PEG), a water-soluble nutritional marker, from the gastrointestinal tract of rat was examined using the [14C]-labeled compound ([14C]PEG) having a molecular weight of 4000. Intravenously injected [14C]PEG was readily excreted and recovered almost completely in the urine and neither hepatic nor renal uptake of the PEG was observed. Intragastrically administered [14C]PEG was eliminated in the urine with an average recovery of only 0.43±0.13% (Mean+S.D., n= 10) of the dose over 24hr. From the gel column chromatographic profile of the radioactivity excreted in the urine after an oral dose, [14C]PEG was suggested to be absorbed in two forms, as an original form and as a low molecular weight component. The latter component might be the degraded product of PEG in the gastrointestinal tract. From these results it was confirmed that PEG with a molecular weight of 4000 is a satisfactory marker because of its low absorbability.
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