Abstract
The antifungal activities of sixty two 2, 4, 6-trihydroxyacylophenones and related compounds against Trichophyton spp. and other fungi were investigated to study their structure-activity relationship.
It was found that the activities of these compounds were closely related to the length of the acyl and alkyl chains attached to the 1, 3, 5-trihydroxybenzene moiety. Among the compounds tested, 2, 4, 6-trihydroxy-3-nonylaeetophenone (V-7) showed the highest activity against Trichophyton spp., with MICs being 1.57μg/ml, and was more active than amphotericin B.
