Epstein-Barr Virus Early Antigen Inducing Activity of 14-O-Derivatives of (-)-Indolactam V

抄録

New 14-O-derivatives of (-)-indolactam V, which has the basic ring-structure of teleocidins without the monoterpenoid moiety, were prepared and their Epstein-Barr virus early antigen (EBV-EA) inducing activity was tested. A series of 14-O-alkyl derivatives was far less active than (-)-indolactam V, but the 14-O-acyl derivatives showed a high EBV-EA inducing activity. These results suggest that the free hydroxyl group at C-14 plays an important role in inducing the EBV-EA, and that the activity of the acyl derivatives arises through hydrolysis of the ester groups.