Spicamycin, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (Ml) and Human Promyelocytic Leukemia Cells (HL-60)

Yoichi HAYAKAWA; Masaya NAKAGAWA; Hiroyuki KAWAI; Kozo TANABE; Hiroshi NAKAYAMA; Akira SHIMAZU; Haruo SETO; Noboru OTAKE

doi:10.1271/bbb1961.49.2685

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Spicamycin, a New Differentiation Inducer of Mouse Myeloid Leukemia Cells (Ml) and Human Promyelocytic Leukemia Cells (HL-60)

Yoichi HAYAKAWA, Masaya NAKAGAWA, Hiroyuki KAWAI, Kozo TANABE, Hiroshi NAKAYAMA, Akira SHIMAZU, Haruo SETO, Noboru OTAKE

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1985 Volume 49 Issue 9 Pages 2685-2691

DOI https://doi.org/10.1271/bbb1961.49.2685

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Abstract

A new antibiotic was obtained from the culture broth of Streptomyces alanosinicus 879-MT₃, and the name spicamycin was given. Spicamycin had a marked effect on the induction of differentiation of human promyelocytic leukemia cells (HL-60) as well as mouse myeloid leukemia cells (Ml). Its structure was elucidated by degradative studies and ¹H and ¹³C NMR spectral analysis as shown in Fig. 1.

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