1985 年 49 巻 9 号 p. 2685-2691
A new antibiotic was obtained from the culture broth of Streptomyces alanosinicus 879-MT3, and the name spicamycin was given. Spicamycin had a marked effect on the induction of differentiation of human promyelocytic leukemia cells (HL-60) as well as mouse myeloid leukemia cells (Ml). Its structure was elucidated by degradative studies and 1H and 13C NMR spectral analysis as shown in Fig. 1.
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