Staurosporine, a Potent Platelet Aggregation Inhibitor from a Streptomyces Species
1986 年 50 巻 11 号 p. 2723-2727
詳細
1986 年 50 巻 11 号 p. 2723-2727
We found a potent platelet aggregation inhibitor in the culture broth of Streptomyces strain M-193. The inhibitor was purified as white crystals and investigated; it was identified as Staurosporine. It strongly inhibited the platelet aggregation induced by collagen or ADP with IC50 values of 3.4μM and 11.6μM, respectively. The inhibitor had no effect on thrombin-induced platelet aggregation or membrane stabilization against heat-induced hemolysis.
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