Optical Resolution of 2-(4-Substituted phenyl)-3-methylbutanoic Acids with Diethylamine by Preferential Crystallization

Hiroyuki NOHIRA; Daiyo TERUNUMA; Shinzi KOBE; Ikuko ASAKURA; Akira MIYASHITA; Tasuku ITO

doi:10.1271/bbb1961.50.675

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Optical Resolution of 2-(4-Substituted phenyl)-3-methylbutanoic Acids with Diethylamine by Preferential Crystallization

Hiroyuki NOHIRA, Daiyo TERUNUMA, Shinzi KOBE, Ikuko ASAKURA, Akira MIYASHITA, Tasuku ITO

Author information

JOURNAL FREE ACCESS

1986 Volume 50 Issue 3 Pages 675-680

DOI https://doi.org/10.1271/bbb1961.50.675

Details

Abstract

(±-2-(4-Substituted phenyl)-3-methylbutanoic acids (2a-c) were optically resolved by preferential crystallization in the form of their diethylamine salts (3a-c).
The molar ratio of the acid to the amine in these salts was found to be 2: 1 by chemical analyses, and was confirmed by analyzing the crystal structure of one of these salts (3b) with X-ray single crystallography.

Content from these authors

This article cannot obtain the latest cited-by information.

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!