1987 Volume 51 Issue 2 Pages 471-476
Allosamidin, a product of Streptomyces sp. No 1713, inhibited Bombyx mori chitinase specifically in a competitive way with a Ki of about 0.1 μM. The effect of allosamidin on chitinases from Streptomyces griseus and Serratia marcescens was weaker, about 1/500 that on B. mori chitinase. Allosamidin did not inhibit yam chitinase, lysozymes of hen egg-white or human urine, or B. mori β-N-acetyl-D-glucosaminidase. The results suggest that allosamidin is a specific inhibitor of the insect chitinase.
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