Unique Spindle Poisons, Curvularin and Its Derivatives, Isolated from Penicillium Species

Akio KOBAYASHI; Tomokazu HINO; Shinji YATA; Tomohiko J. ITOH; Hidemi SATO; Kazuyoshi KAWAZU

doi:10.1271/bbb1961.52.3119

Agricultural and Biological Chemistry

Online ISSN : 1881-1280
Print ISSN : 0002-1369
ISSN-L : 0002-1369

Unique Spindle Poisons, Curvularin and Its Derivatives, Isolated from Penicillium Species

Akio KOBAYASHI, Tomokazu HINO, Shinji YATA, Tomohiko J. ITOH, Hidemi SATO, Kazuyoshi KAWAZU

Author information

JOURNAL FREE ACCESS

1988 Volume 52 Issue 12 Pages 3119-3123

DOI https://doi.org/10.1271/bbb1961.52.3119

Details

Abstract

Curvularin, 8-dehydrocurvularin, and 8-hydroxycurvularin as well as a minor new metabolite, 8-methoxycurvularin, were isolated as fungal metabolites having cytotoxic activity toward sea urchin embryogenesis. Curvularin induced barrel-shaped mitotic spindles and 8-dehydrocurvularin caused miniature spindles. They were shown to act on components of the mitotic apparatus and to effectively inhibit cell division.

Content from these authors

This article cannot obtain the latest cited-by information.

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!