Shizukanolides D, E and F, Novel Lindenanolides from Chlomnthus spp. (Chloranthaceae)

Abstract

Three novel sesquiterpene lactones having a unique lindenane skeleton were isolated from Chlomnthus spp. (Chloranthaceae). The first one, shizukanolide D (1), was found in ether extracts of C. japonicus Sieb., Hitorishizuka, and characterized to be an epoxy derivative of previously known chloranthalactone C (3). The other two compounds, shizukanolides E (4) and F (6), were isolated from ether extracts of C. sermtus (Thumb.) Roem. et Schult., Futarishizuka, and their structures were determined to be hydroxy derivatives of shizukanolide C (2).