Biological Activity of Nitrophlorophenone Derivatives

Abstract

A series of nitrophlorophenone derivatives of grandinol, a potent inhibitor of germination and photosynthetic electron transport (PET) in Eucalyptus grandis, was synthesized and their activities on cress seed germination and on the PET system were determined. In general, the nitrophlorophenone derivatives were found to inhibit both cases. Studies on the structure-activity relationships of those compounds indicated that nitrophlorophenone derivatives with an alkyl group on the nuclus may interact with receptor sites in a similar manner to that of grandinol, whereas those without the alkyl substituent may behave in a different manner.