Structure of Amino Acids Isolated from Hydrolyzed HV-Toxin M, a Host-specific Toxin-related Compound Produced by Helminthosporium victoriae

Abstract

The chemistry of several of the specific toxins isolated from a culture medium of the phytopathogenic fungus Helminthosporium victoriae, a causal agent of Victoria blight disease of oat, was studied. The structures of the amino acid components of the isolated HV-toxin M were identified, and the absolute configurations of the asymmetric α-carbons were elucidated as (S) (I - V, Fig. 1), (S) for C-3 of 3-OH-leucine (II), (R) for C-3 of 3-OH-lysine (V) and (Z)for 3-chlorodehydroalanine (VII).
The structure of the other toxin simultaneously isolated, HV-toxin H, was found to be identical with victorin C.