Structure of the Novel Insecticidal Sesquilignan, Haedoxan A

抄録

Haedoxan A, a new insecticidal sesquilignan, was isolated from the root of Hae-doku-sou, Phryma leptostachya L., and the structure was elucidated as a l-hydroxy-2-[(2, 6-dimethoxy-3, 4-methylenedioxyphenyl)oxy]-6-[6/-methoxy-2'-methoxymethyl-3/-(3, 4-methylenedioxyphenyl)-2/, 3'dihydro-r, 4'-benzodioxin-7'-yl]-3, 7-dioxabicyclo[3.3.0]octane on the basis of spectroscopic and chemical information involving syntheses of its partial structures. Its relative stereochemistry was revealed to be (1S^*, 2R^*, 5R^*, 6S^*, 2'R^*, 3'R^*) or (1S^*, 2R^*, 5R^*, 6S^*, 2'S^*, 3'S^*).