Synthesis and Immunoadjuvant Activity of the Conjugates of 1-Thio-N-acetyl-muramoyl Dipeptide with Lipid A Subunit Analogs

抄録

A variety of immunomodulators were synthesized by combining biologically active derivatives of 1-thio-muramoyl dipeptide with 4-O-phosphono-D-glucosamine derivatives related to bacterial lipid A, and using the (succinoylamino)undecanoyl group as a spacer. Their immunoadjuvant activities in guinea-pigs were examined.