Abstract
In order to find out some specific blockers of the membrane transport of amino acids and small peptides in animal small intestine and kidney, the following dihydrochalcone (DHC)-amino acid and -peptide conjugates were synthesized. [N-[(6'-hydroxy-4, 4'-dimethoxy-DHC)-2'-yloxy]acetylglycyl]glycine, Nε-[(6'-hydroxy-4, 4'-dimethoxy-DHC)-2'-yloxy]acetylIysine, O-[(6'-hydroxy-4, 4'-dimethoxy-DHC)-2'-yl]homoserine, [O-[(6'-hydroxy-4, 4'-dimethoxy-DHC)-2'-yl]homoseryl]glycine, N-glycyl-O-[(6'-hydroxy-4, 4'-dimethoxy-DHC)-2'-yl]homoserine, and [O-[(4, 4', 6'-trihydroxy-DHC)-2'-yl]homoseryl]glycine.
