Syntheses and Biological Activities of (±)-Streptovitacin A and E-73

Abstract

(±)-Streptovitacin A (1) and its stereoisomers were synthesized by an aldol reaction of (±)-2, 4-dimethyl-4-trimethyIsiloxy-1-cyclohexanones (4b and 9) with 4-(2-oxoethyl)-2, 6-piperidinedione (5). E-73 (2) was derived from synthetic 1. (±)-1 showed moderate growth inhibition against fungi and lettuce seeds.