Nutritional Effects of an Oligopeptide Mixture with a Very High Fischer Ratio on the Amino Acid Absorption and Cerebral Amine Metabolism in Rats Suffering from Galactosamine-induced Liver Injurry

抄録

We have proposed 21 method to produce an oligopeptide mixture from zein by enzymatic modification to improve the Fischer ratio. In this study we produced the oligopeptide mixture on an enlarged scale and evaluated it in comparison with a corresponding amino acid mixture by feeding tests with normal and liver-injured rats. Both of the oligopeptide mixture and the amino acid mixture enhanced the Fischer ratio in plasma and brain at a similar degree. In rats suffering from severe hepatic injury, undesirable aromatic amino acids were absorbed from the oligopeptide mixture to a less extent than from the amino acid mixture. Peptide feeding, as well as amino acid feeding, resulted in decreasing concentrations of tryptophan and serotonin and in keeping the concentrations of dopamine and norepinephrine in cerebrum. These results suggest that the oligopeptide mixture is useful for patients with severe heptic disease.