Isolation and Synthesis of a New Bio-antimutagen, Petasiphenol, from Scapes of Petasites japonicum

Ryozo IRIYE; Kohji FURUKAWA; Ritsuo NISHIDA; Chul-sa KIM; Hiroshi FUKAMI

doi:10.1271/bbb.56.1773

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Isolation and Synthesis of a New Bio-antimutagen, Petasiphenol, from Scapes of Petasites japonicum

Ryozo IRIYE, Kohji FURUKAWA, Ritsuo NISHIDA, Chul-sa KIM, Hiroshi FUKAMI

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JOURNAL FREE ACCESS

1992 Volume 56 Issue 11 Pages 1773-1775

DOI https://doi.org/10.1271/bbb.56.1773

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Abstract

A new bio-antimutagen, petasiphenol [3-(3, 4-dihydroxyphenyl)-2-oxopropyl caffeate](1) was isolated from scapes of Petasites japonicum (AD₅₀=95 μg/ml against UV-induced mutagenic E. coli WP2 B/r Trp^-. Petasiphenol (1) and its isomer (2) were synthesized. The activity of 1 was observed in the presence of soybean oil (glyceride), although the isomer (2) did not show any activity in doses up to 300 μg/ml.

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