Effects of L-156, 602, a C5a Receptor Antagonist, on Mouse Experimental Models of Inflammation

Abstract

L-156, 602, a C5a receptor antagonist, was found as an immunosuppressant with preferential effects on delayed-type hypersensitivity (DTH) in our screening program and it was shown that L-156, 602, supressed the efferent phase of DTH. Here, we tested its efffects on experimental models of inflammation induced in mice. L-156, 602 did not suppress serotonin- and carrageenan- induced inflammation while it completely suppressed concanavalin A-induced inflammation 4 h after elicitation. The inflammation appeared 24 h after the elicitation with concanavalin A and it was significantly suppressed by L-156, 602. Muramyl dipeptide (MDP)-induced acute joint inflammation was also significantly suppressed by L-156, 602. These results demonstrated the unique immunomodulating properties of L-156, 602 in mouse experimental models of inflammation.