Polymyxin B Enhances Formation of a New Pigment, a Peptide-Ferropyrimine Complex, in Serratia marcescens

Abstract

We previously isolated a Serratia marcescens O5 : H1 Z-54 strain which produces a new reddish-violet pigment, a peptide-ferropyrimine complex. This study showed that polymyxin B enhances the formation of the pigment about threefold. This occurs because polymyxin B in the medium causes the formation of an iron-polymyxin B complex which imposes a low iron stress on the bacteria and, in turn, enhances pigment production. This shows that polymyxin B is both a membrane-disrupting and ionophoric antibiotic.