Identification of a Nuclear Retinoic Acid-binding Activity Representative of Endogeneous Retinoic Acid Receptors in the Nuclei of Rat Liver and Testis

Hiroshi Mano; Chiyoko Kumakura; Akemi Kitamura; Hikaru Morino; Shigeaki Kato; Shoichi Masushige

doi:10.1271/bbb.57.1400

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Identification of a Nuclear Retinoic Acid-binding Activity Representative of Endogeneous Retinoic Acid Receptors in the Nuclei of Rat Liver and Testis

Hiroshi Mano, Chiyoko Kumakura, Akemi Kitamura, Hikaru Morino, Shigeaki Kato, Shoichi Masushige

Author information

JOURNAL FREE ACCESS

1993 Volume 57 Issue 8 Pages 1400-1402

DOI https://doi.org/10.1271/bbb.57.1400

Details

Abstract

We found a nuclear RA-binding activity by using a sucrose-density-gradient assay from rat liver and testis. From the sedimentation analysis, and the comparison with cloned RARs, it is likely that these binding activities represent endogenous RARs. Furthermore we showed that these binding activities were constant irrespective of the retinoid status in the rat.

Content from these authors

This article cannot obtain the latest cited-by information.

Favorites & Alerts

Corresponding author

Register with J-STAGE for free!