Amphotericin B Resistance Assay for the Detection of Cholesterol Biosynthesis Inhibitors
1994 年 58 巻 7 号 p. 1321-1323
詳細
1994 年 58 巻 7 号 p. 1321-1323
Three different types of cholesterol biosynthesis inhibitors, lovastatin, ketoconazole, and 25-hydroxycholesterol, showed their respective resistance against amphotericin B (AmB) cytotoxicity in Chinese hamster ovary (CHO)-K1 cells. The negative correlation between the acquisition of AmB resistance and the decrease of cellular cholesterol content by the inhibitor was confirmed.
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