Enhancement of Mutagenic Activity of 9-Aminoacridine by Introducing a Nitro Group into the Molecule
1994 年 58 巻 8 号 p. 1420-1423
詳細
1994 年 58 巻 8 号 p. 1420-1423
Mutagenic activity and DNA intercalation were examined for 9-aminoacridine (9-AA) and its deriva-tives. Introduction of a nitro group into the 9-AA molecule was found to enhance the activity enormously as was detected by the Ames test. Acetylation of amino group at 9-position of acridine ring inhibited the intercalation, the frameshift activity disappearing. Rat liver S9 converted 9-AA metabolically to 9-amino-2-hydroxyacridine.
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