1994 年 58 巻 9 号 p. 1627-1631
To clarify the absolute configurations of antafumicins A and B, which are antifungal substances from Aspergillus niger NH-401, the total synthesis of (2S)-antafumicins was accomplished by starting from (S)-malic acid in 12 steps. Based upon the physicochemical data of the synthetic samples, the absolute configurations of naturally occurring antafumicins A and B were determined as (2R, 4S)- and (2R, 4R)-4-(3-acetyl-2, 6-dihydroxyphenyl)-2-methoxy-4-butanolide, respectively.
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