Inhibition of T Cell Receptor-mediated Signal Transduction by Erbstatin

Abstract

Erbstatin, a tyrosine kinase inhibitor, inhibited p59^fyn- and p56^1ck-kinases in vitro with IC₅₀s of 0.21 and 0.18μg/ml, respectively. Inositol phosphates formation, enhanced by anti-CD3, wasalso inhibited by erbstatin. Moreover, erbstatin treatment prevented anti-CD3-induced interleukin 2 (IL-2) production, but phorbol ester-induced IL-2 production was not affected by erbstatin.