Reparative Effect of Nicotinamide and Nicotinic Acid on the Aggravation of Tryptophan-nicotinamide Metabolism Caused by 6-Aminonicotinamide

Abstract

It is known that the abnormal metabolism of tryptophan is caused by feeding a diet containing 6-aminonicotinamide. However, when rats were fed with a diet containing a large amount of nicotinic acid or nicotinamide, no aggravation of tryptophan metabolism was observed. We found that nicotinamide and nicotinic acid completely repaired the disturbance of tryptophan metabolism caused by 6-aminonicotinamide.