Synthesis of Both the Enantiomers of Aseanostatin P5(Sarcinic Acid), an Inhibitor of Myeloperoxidase Release, and Four Diastereomers of Aggreceride A, a Platelet Aggregation Inhibitor

Abstract

Both the enantiomers of aseanostatin P5(sarcinic acid), an inhibitor of myeloperoxidase(MPO)release from human polymorphonuclear leukocytes(PMN), with high optical purity were synthesized by starting from (S)-2-methylbutanol and methyl (S)-3-hydroxy-2-methylpropanoate. They were converted to four diastereomers of aggreceride A, a platelet aggregation inhibitor.