Increase in the Level of mRNA for 3-Hydroxyanthranilate 3, 4-Dioxygenase in Brain of Epilepsy-prone El Mice

Yukinori Nakagawa; Hiroshi Asai; Junzoh Kitoh; Hitoshi Mori; Kiwao Nakano

doi:10.1271/bbb.59.2191

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Increase in the Level of mRNA for 3-Hydroxyanthranilate 3, 4-Dioxygenase in Brain of Epilepsy-prone El Mice

Yukinori Nakagawa, Hiroshi Asai, Junzoh Kitoh, Hitoshi Mori, Kiwao Nakano

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JOURNAL FREE ACCESS

1995 Volume 59 Issue 11 Pages 2191-2192

DOI https://doi.org/10.1271/bbb.59.2191

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Abstract

We had shown that production of quinolinic acid is high in the brain of epilepsy-prone El mice and that this is due to an increase in the activity of 3-hydroxyanthranilate 3, 4-dioxygenase (3-HAO, EC 1.13.11.6). We demonstrated here that the level of mRNA for 3-HAO was markedly increased in the brain of El mice.

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