Inhibition of the Endothelin-converting Enzyme by Pepsin Digests of Food Proteins

Misako Okitsu; Akihito Morita; Makoto Kakitani; Mamoru Okada; Hidehiko Yokogoshi

doi:10.1271/bbb.59.325

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Inhibition of the Endothelin-converting Enzyme by Pepsin Digests of Food Proteins

Misako Okitsu, Akihito Morita, Makoto Kakitani, Mamoru Okada, Hidehiko Yokogoshi

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JOURNAL FREE ACCESS

1995 Volume 59 Issue 2 Pages 325-326

DOI https://doi.org/10.1271/bbb.59.325

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Abstract

Inhibitory activities toward the endothelin-converting enzyme (ECE) were detected in pepsin digests of bonito pyrolic appendix and beef. After Sep-Pak C₁₈ fractionation, this activity from bonito and beef was recovered in the 50% and 25% ethanol fractions, respectively. Activities were also recovered in the ultrafiltrate (<5000 Da), and disappeared after a pronase treatment. Therefore, these inhibitory activities may have peptidic properties.

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