Insulin-stimulated Polypeptide Chain Elongation in the Soleus Muscle of Mice

Abstract

The effect of insulin on polypeptide chain elongation was examined in soleus muscles isolated from 18hour-fasted mice. Treatment with insulin for 1hour increased the elongation rate, which was estimated by the half-transit time. This suggests that insulin stimulated protein synthesis by modifying the elongation rate in addition to the initiation rate.