Simple Determination of Cyclopiazonic Acid

Abstract

A simple determination of cyclopiazonic acid by HPLC is elucidated. The zinc cation in the mobile phase and indomethacin as an internal standard made quantitation higher and peak identification of cyclopiazonic acid easier. In the combination with a TLC analysis, production of cyclopiazonic acid by some species of aspergilli could be analyzed both in a liquid culture and in a solid culture on wheat bran without a prior clean-up operation.