Syntheses of 1-O-[5-(Carboxy)pentanoyl]-2-deoxy-2-(2, 2-difluorotetradecanamido)-3-O-[(R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phosphono-α-D-glucopyranose and Its Analogues

Masao Shiozaki; Hideki Miyazaki; Masami Arai; Tetsuo Hiraoka; Shin-ichi Kurakata; Tohoru Tatsuta; Junko Ogawa; Masahiro Nishijima; Yuzuru Akamatsu

doi:10.1271/bbb.59.501

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Syntheses of 1-O-[5-(Carboxy)pentanoyl]-2-deoxy-2-(2, 2-difluorotetradecanamido)-3-O-[(R)-3-(tetradecanoyloxy)tetradecanoyl]-4-O-phosphono-α-D-glucopyranose and Its Analogues

Masao Shiozaki, Hideki Miyazaki, Masami Arai, Tetsuo Hiraoka, Shin-ichi Kurakata, Tohoru Tatsuta, Junko Ogawa, Masahiro Nishijima, Yuzuru Akamatsu

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ジャーナルフリー

1995 年 59 巻 3 号 p. 501-506

DOI https://doi.org/10.1271/bbb.59.501

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抄録

1-O-[5-(Carboxy) pentanoyl]-2-deoxy-2-(2, 2-difluorotetradecanamido)-3-O-[(R)-3-(tetradecanoyl-oxy)tetradecanoyl]-4-O-phosphono-α-D-glucopyranose (13) and its analogues (16 and 19) were synthesized. Compound 13 showed strong LPS-agonistic activity.

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Bulletin of the Agricultural Chemical Society of Japan

Agricultural and Biological Chemistry

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