Antimutagenic Effect of Methanolic Extracts from Peanut Hulls

Abstract

The antimutagenic effects of methanolic extracts of peanut hulls (MEPH) were evaluated by the Ames test. MEPH inhibited the mutagenicity of 4-nitroquinoline-N-oxide (NQNO), a direct-acting mutagen. MEPH also inhibited the mutagenicity of some indirect-acting mutagens and decreased in the order of 2-amino-3-methyl-imidazo(4, 5-f)quinoline (IQ)> aflatoxin B₁ (AFB₁)>2-amino-6-methyldipyrido(1, 2-a:3', 2'-d)imidazole (Glu-P-1)>3-amino-1, 4-dimethyl-5H-pyridol(4, 3-b)indole (Trp-P-1)> benzo(a)pyrene (B(a)P) for S. typhimurium TA98, and IQ>Trp-P-1>Glu-P-1>AFB₁>B(a)P for S. typhimurium TA100.