Kojistatin A, a New Cysteine Protease Inhibitor Produced by Aspergillus oryzae

Nobuyoshi SATO; Tatsuo HORIUCHI; Mitsutoshi HAMANO; Hiroshi SEKINE; Satoru CHIBA; Hiroki YAMAMOTO; Takeya YOSHIOKA; Ikuo KIMURA; Mikio SATAKE; Yoshiteru IDA

doi:10.1271/bbb.60.1747

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Kojistatin A, a New Cysteine Protease Inhibitor Produced by Aspergillus oryzae

Nobuyoshi SATO, Tatsuo HORIUCHI, Mitsutoshi HAMANO, Hiroshi SEKINE, Satoru CHIBA, Hiroki YAMAMOTO, Takeya YOSHIOKA, Ikuo KIMURA, Mikio SATAKE, Yoshiteru IDA

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Keywords: Aspergillus oryzae, kojistatin A, cysteine protease inhibitor

JOURNAL FREE ACCESS

1996 Volume 60 Issue 10 Pages 1747-1748

DOI https://doi.org/10.1271/bbb.60.1747

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Abstract

A new cysteine protease inhibitor, named kojistatin A, was found in the extract of a solid culture of Aspergillus oryzae ATCC 20386. The structure of kojistatin A was determined on the basis of chemical and spectroscopic evidence. Kojistatin A specifically inhibited cysteine proteases such as papain, ficin, and bromelain.

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