Inhibitory Effect of Dietary Wheat Bran on Formation of Aberrant Crypt Foci in Rat Colon Induced by a Single Injection of 1, 2-Dimethylhydrazine

Abstract

The frequency of appearance of aberrant crypt foci (ACF) in the distal colon was significantly lower in rats fed a high fiber (20% wheat bran) diet than in those fed a fiber-free one at 4 weeks after a single injection of 1, 2-dimethylhydrazine (DMH, 20 mg/kg), although crypt/ACF was high in the former relative to the latter. This result suggests that dietary wheat bran effectively serves as a regulator of ACF frequency at early stages after DMH injection.