Glycerol-3-phosphate Dehydrogenase Inhibitors, Anacardic Acids, from Ginkgo biloba

Abstract

Four inhibitors of glycerol-3-phosphate dehydrogenase were isolated from Ginkgo biloba and identified as anacardic acids (6-tridecylsalicylic acid, 6-[(8Z)-pentadecenyl]salicylic acid, 6-[(9Z, 12Z)-heptadecadienyl]salicylic acid, and 6-[(8Z)-heptadecenyl]salicylic acid) by instrumental analyses. Their 50% inhibitory concentrations against the enzyme were 1-3μg/ml under the standard assay conditions. Anacardic acid inhibited the enzyme non-competitively. The sarcotesta contained most of anacardic acids, and nuts a little.