Syntheses of (14β, 17α)-14-Hydroxy- and (14β, 17α)-2, 14-Dihydroxyestradiols and Their Activities

Abstract

Structure 1 is proposed for the Inagami-Tamura endogenous digitalis-like factor (EDLF), and (14β, 17α)-14-hydroxy- and (14β, 17α)-2, 14-dihydroxyestradiols (2 and 3) were synthesized as model# for studies on 1. The latter compound was remarkably potent in inducing a contractile response in isolated rat aorta and guinea pig left atrium.