Impaired Pancreatic Acinar Sensitivity to Cholecystokinin But Not to Carbachol in Rats with Chronic Bile Pancreatic Juice Diversion

Abstract

Changes in the sensitivity and responsiveness to CCK and cholinergic stimuli were examined in isolated pancreatic acini prepared from 7-day BPJ-diverted rats. The sensitivity to CCK was lower in BPJ-diverted rats than in the control rats, but the sensitivity to the cholinergic agonist, carbachol, was not changed. These results suggest that the contribution of the cholinergic pathway to pancreatic enhancement by feeding dietary protein can be increased after chronic BPJ diversion.