Bioscience, Biotechnology, and Biochemistry
Online ISSN : 1347-6947
Print ISSN : 0916-8451
A Facile Synthesis of (R)-3-Amino-4-phenylbutyric Acid from L-Aspartic Acid
Masahiko SEKI, Kazuo MATSUMOTO
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Keywords: P-amino acid, L-aspartic acid, 4-phenyl-3-aminobutyric acid, Friedel-Crafts acylation, α-aminoketone
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1996 Volume 60 Issue 5 Pages 916-917

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Abstract
A practical synthesis of (R)-3-amino-4-phenylbutyric acid 1, based on Friedel-Crafts acylation with the α-aminocarboxyl group of L-aspartic acid retaining its original α-carbon chirality, is described.
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