Isolation and Structure of staph-cAM373 Produced by Staphylococcus aureus That Induces Conjugal Transfer of Enterococcus faecalis Plasmid pAM373

Jiro NAKAYAMA; Shigeru IGARASHI; Hiromichi NAGASAWA; Don B. CLEWELL; Florence Y. AN; Akinori SUZUKI

doi:10.1271/bbb.60.1038

Jiro NAKAYAMA, Shigeru IGARASHI, Hiromichi NAGASAWA, Don B. CLEWELL, Florence Y. AN, Akinori SUZUKI

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Keywords: Enterococcus faecalis, Staphylococcus aureus, peptide sex pheromone, conjugative plasmid transfer, amino acid sequence

JOURNAL FREE ACCESS

1996 Volume 60 Issue 6 Pages 1038-1039

DOI https://doi.org/10.1271/bbb.60.1038

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Abstract

Enterococus faecalis plasmid pAM373 encodes a mating response to the sex pheromone, cAM373, which is secreted from pAM373-free E. faecalis. cAM373-like activity was detected in a culture filtrate of Staphylococcus aureus. The major active substance, termed staph-cAM373, was isolated, and its structure was identified as a H-Ala-Ile-Phe-Ile-Leu-Ala-Ala-OH heptapeptide.

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