A New Cytotoxic Cholestane Bisdesmoside from Ornithogalum saundersiae Bulbs

Yoshihiro MIMAKI; Minpei KURODA; Aiko KAMEYAMA; Yutaka SASHIDA; Toshihiko HIRANO; Kitaro OKA; Kazuo KOIKE; Tamotsu NIKAIDO

doi:10.1271/bbb.60.1049

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

A New Cytotoxic Cholestane Bisdesmoside from Ornithogalum saundersiae Bulbs

Yoshihiro MIMAKI, Minpei KURODA, Aiko KAMEYAMA, Yutaka SASHIDA, Toshihiko HIRANO, Kitaro OKA, Kazuo KOIKE, Tamotsu NIKAIDO

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Keywords: cholestane bisdesmoside, Ornithogalum saundersiae, cytotoxic activity, HL-60 cells, MOLT-4 cells

JOURNAL FREE ACCESS

1996 Volume 60 Issue 6 Pages 1049-1050

DOI https://doi.org/10.1271/bbb.60.1049

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Abstract

Bioassay-guided fractionation of the MeOH extract of Ornithogalum saundersiae bulbs led to the isolation of a new cholestane bisdesmoside with potent cytotoxic activities toward leukemia HL-60 and MOLT-4 cells. The structure was deduced mainly from spectroscopic information.

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