Conversion of Glutathione into Cadystins and Their Analogs Catalyzed by Carboxypeptidase Y

抄録

Cadystins induced in a fission yeast treated with Cd²⁺ are the higher homologs of glutathione. In the present work, glutathione was incubated with Carboxypeptidase Y at a high substrate concentration. The reaction afforded not only the degraded product, but also cadystins and their analogs. A possible transformation pathway for glutathione by this enzyme is proposed.