1996 年 60 巻 9 号 p. 1391-1400
Nitrile hydratase (NHase) was discovered in our laboratory. This enzyme was purified and characterized from various microorganisms. NHases are roughly classified into two groups according to the metal involved: Fe-type and Co-type. NHases are expected to have great potential as catalysts in organic chemical processing because they can convert nitriles to the corresponding higher-value amides under mild conditions. We have used microbial enzymes for the production of useful compounds; NHase has been used for the industrial production (production capacity: 30, 000 tons/year) of acrylamide from acrylonitrile. This is the first successful example of a biotransformation process for the manufacture of a commodity chemical. This review summarizes the history of NHase studied not only from a basic standpoint but also from an applied point of view.
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