Inhibition of Escherichia coli Heat-labile Enterotoxin by an Amino Carbonyl Product, Lactose-α-lactalbumin

Kan SHIDA; Kotaro TAKAMIZAWA; Toshiaki OSAWA

doi:10.1271/bbb.60.1492

Bioscience, Biotechnology, and Biochemistry

Online ISSN : 1347-6947
Print ISSN : 0916-8451

Inhibition of Escherichia coli Heat-labile Enterotoxin by an Amino Carbonyl Product, Lactose-α-lactalbumin

Kan SHIDA, Kotaro TAKAMIZAWA, Toshiaki OSAWA

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Keywords: Escherichia coli heat-labile enterotoxin (LT), lactose-protein amino carbonyl product, receptor analogue

JOURNAL FREE ACCESS

1996 Volume 60 Issue 9 Pages 1492-1494

DOI https://doi.org/10.1271/bbb.60.1492

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Abstract

The inhibition by lactose-α-lactalbumin amino carbonyl product of Escherichia coli heat-labile enterotoxin was studied by GM1-ELISA and by assay with CHO-K1 cells. The product dose-dependently inhibited the binding of the enterotoxin to GM1 gan-glioside and decreased the morphological change of CHO-K1 cells caused by this toxin. The results suggest that this product may be a receptor analogue in the intestine.

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